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FORD LAB PUBS!
Recent Publications from Ford Laboratory/Collaborators (2012-2020)

Link to Ford lab publications: www.ncbi.nlm.nih.gov/pubmed/?term=Ford+HL+colorado​

1: Kong D, Hughes CJ, Ford HL. Cellular Plasticity in Breast Cancer Progression and Therapy. Front Mol Biosci. 2020 Apr 24;7:72. doi: 10.3389/fmolb.2020.00072. PMID: 32391382; PMCID: PMC7194153.

2: Zhou H, Blevins MA, Hsu JY, Kong D, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MU, Ramirez D, Zhang L, Pineiro JT, Mathews Griner L, King R, Barnaeva E, Hu X, Southall NT, Ferrer M, Gustafson DL, Regan DP, D'Alessandro A, Costello JC, Patnaik S, Marugan J, Zhao R, Ford HL. A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis. Cancer Res. 2020 Apr 27:canres.0435.2020. doi: 10.1158/0008-5472.CAN-20-0435. Epub ahead of print. PMID: 32341035.

3: Oliphant MUJ, Kong D, Zhou H, Lewis MT, Ford HL. Two Sides of the Same Coin: The Role of Developmental pathways and pluripotency factors in normal mammary stem cells and breast cancer metastasis. J Mammary Gland Biol Neoplasia. 2020 Apr 22. doi: 10.1007/s10911-020-09449-0. Epub ahead of print. PMID: 32323111.

4: Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, García de Herreros A, Goodall GJ, Hadjantonakis AK, Huang RJY, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Massagué J, Mayor R, McClay D, Mostov KE, Newgreen DF, Nieto MA, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler MP, Takahashi Y, Takeichi M, Theveneau E, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G; EMT International Association (TEMTIA). Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 Apr 16. doi: 10.1038/s41580-020-0237-9. Epub ahead of print. PMID: 32300252.

5: Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C. Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8. PMID: 31285279; PMCID: PMC6726557.

6: Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program. Cancer Res. 2019 Feb 15;79(4):720-734. doi: 10.1158/0008-5472.CAN-18-1791. Epub 2019 Jan 3. PMID: 30606720; PMCID: PMC6586234.

7: Neelakantan D, Zhou H, Oliphant MUJ, Zhang X, Simon LM, Henke DM, Shaw CA, Wu MF, Hilsenbeck SG, White LD, Lewis MT, Ford HL. Publisher Correction: EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun. 2018 Nov 12;9(1):4720. doi: 10.1038/s41467-018-07168-z. Erratum for: Nat Commun. 2017 Jun 12;8:15773. PMID: 30420638; PMCID: PMC6232083.

8: Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Author Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 Sep 17;9(1):3830. doi: 10.1038/s41467-018-06265-3. Erratum for: Nat Commun. 2018 Mar 13;9(1):1047. PMID: 30224630; PMCID: PMC6141458.

9: Vartuli RL, Zhou H, Zhang L, Powers RK, Klarquist J, Rudra P, Vincent MY, Ghosh D, Costello JC, Kedl RM, Slansky JE, Zhao R, Ford HL. Eya3 promotes breast tumor-associated immune suppression via threonine phosphatase-mediated PD-L1 upregulation. J Clin Invest. 2018 Jun 1;128(6):2535-2550. doi: 10.1172/JCI96784. Epub 2018 May 14. PMID: 29757193; PMCID: PMC5983346.

10: Guarnieri AL, Towers CG, Drasin DJ, Oliphant MUJ, Andrysik Z, Hotz TJ, Vartuli RL, Linklater ES, Pandey A, Khanal S, Espinosa JM, Ford HL. The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L. Oncogene. 2018 Jul;37(28):3879-3893. doi: 10.1038/s41388-018-0239-7. Epub 2018 Apr 17. PMID: 29662198; PMCID: PMC6043359.

11: Zhang L, Zhou H, Li X, Vartuli RL, Rowse M, Xing Y, Rudra P, Ghosh D, Zhao R, Ford HL. Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nat Commun. 2018 Mar 13;9(1):1047. doi: 10.1038/s41467-018-03327-4. Erratum in: Nat Commun. 2018 Sep 17;9(1):3830. PMID: 29535359; PMCID: PMC5849647.

12: Zhou H, Zhang L, Vartuli RL, Ford HL, Zhao R. The Eya phosphatase: Its unique role in cancer. Int J Biochem Cell Biol. 2018 Mar;96:165-170. doi: 10.1016/j.biocel.2017.09.001. Epub 2017 Sep 5. PMID: 28887153; PMCID: PMC5808901.

13: Neelakantan D, Zhou H, Oliphant MUJ, Zhang X, Simon LM, Henke DM, Shaw CA, Wu MF, Hilsenbeck SG, White LD, Lewis MT, Ford HL. EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun. 2017 Jun 12;8:15773. doi: 10.1038/ncomms15773. Erratum in: Nat Commun. 2018 Nov 12;9(1):4720. PMID: 28604738; PMCID: PMC5472791.

14: Tavares ALP, Cox TC, Maxson RM, Ford HL, Clouthier DE. Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development. Development. 2017 Jun 1;144(11):2021-2031. doi: 10.1242/dev.145144. Epub 2017 Apr 28. PMID: 28455376; PMCID: PMC5482985.

15: Dimberg LY, Towers CG, Behbakht K, Hotz TJ, Kim J, Fosmire S, Porter CC, Tan AC, Thorburn A, Ford HL. A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance. Mol Cancer Res. 2017 Apr;15(4):382-394. doi: 10.1158/1541-7786.MCR-16-0234. Epub 2017 Jan 20. PMID: 28108622; PMCID: PMC5380511.

16: Kendrick AA, Schafer J, Dzieciatkowska M, Nemkov T, D'Alessandro A, Neelakantan D, Ford HL, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming. Oncotarget. 2017 Jan 24;8(4):6742-6762. doi: 10.18632/oncotarget.14272. PMID: 28039486; PMCID: PMC5341751.

17: Thorburn J, Staskiewicz L, Goodall ML, Dimberg L, Frankel AE, Ford HL, Thorburn A. Non-cell-autonomous Effects of Autophagy Inhibition in Tumor Cells Promote Growth of Drug-resistant Cells. Mol Pharmacol. 2017 Jan;91(1):58-64. doi: 10.1124/mol.116.106070. Epub 2016 Nov 9. PMID: 27974637; PMCID: PMC5198514.

18: Zhou H, Neelakantan D, Ford HL. Clonal cooperativity in heterogenous cancers. Semin Cell Dev Biol. 2017 Apr;64:79-89. doi: 10.1016/j.semcdb.2016.08.028. Epub 2016 Aug 28. PMID: 27582427; PMCID: PMC5330947.

19: Towers CG, Ford HL. A tale of two ends. Cell Cycle. 2016 Jun 17;15(12):1523-4. doi: 10.1080/15384101.2016.1171652. Epub 2016 Apr 21. PMID: 27101085; PMCID: PMC4934064.

20: Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MUJ, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, Ford HL. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nat Commun. 2015 Dec 21;6:10077. doi: 10.1038/ncomms10077. PMID: 26687066; PMCID: PMC4703841.

21: Drasin DJ, Guarnieri AL, Neelakantan D, Kim J, Cabrera JH, Wang CA, Zaberezhnyy V, Gasparini P, Cascione L, Huebner K, Tan AC, Ford HL. TWIST1-Induced miR-424 Reversibly Drives Mesenchymal Programming while Inhibiting Tumor Initiation. Cancer Res. 2015 May 1;75(9):1908-21. doi: 10.1158/0008-5472.CAN-14-2394. Epub 2015 Feb 25. PMID: 25716682; PMCID: PMC4417413.

22: Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. The SIX1-EYA transcriptional complex as a therapeutic target in cancer. Expert Opin Ther Targets. 2015 Feb;19(2):213-25. doi: 10.1517/14728222.2014.978860. Epub 2015 Jan 2. PMID: 25555392; PMCID: PMC4336540.

23: Neelakantan D, Drasin DJ, Ford HL. Intratumoral heterogeneity: Clonal cooperation in epithelial-to-mesenchymal transition and metastasis. Cell Adh Migr. 2015;9(4):265-76. doi: 10.4161/19336918.2014.972761. Epub 2014 Oct 16. PMID: 25482627; PMCID: PMC4594578.

24: Wang CA, Drasin D, Pham C, Jedlicka P, Zaberezhnyy V, Guney M, Li H, Nemenoff R, Costello JC, Tan AC, Ford HL. Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression. Cancer Res. 2014 Dec 15;74(24):7357-70. doi: 10.1158/0008-5472.CAN-14-0666. Epub 2014 Oct 27. PMID: 25348955; PMCID: PMC4268359.

25: Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. PMID: 24755226; PMCID: PMC4047403.

26: O'Brien JH, Hernandez-Lagunas L, Artinger KB, Ford HL. MicroRNA-30a regulates zebrafish myogenesis through targeting the transcription factor Six1. J Cell Sci. 2014 May 15;127(Pt 10):2291-301. doi: 10.1242/jcs.143677. Epub 2014 Mar 14. PMID: 24634509; PMCID: PMC4021474.

27: Kohrt D, Crary J, Zimmer M, Patrick AN, Ford HL, Hinds PW, Grossel MJ. CDK6 binds and promotes the degradation of the EYA2 protein. Cell Cycle. 2014;13(1):62-71. doi: 10.4161/cc.26755. Epub 2013 Oct 12. PMID: 24196439; PMCID: PMC3925736.

28: Cieply B, Farris J, Denvir J, Ford HL, Frisch SM. Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2. Cancer Res. 2013 Oct 15;73(20):6299-309. doi: 10.1158/0008-5472.CAN-12-4082. Epub 2013 Aug 13. PMID: 23943797; PMCID: PMC3806457.

29: Patrick AN, Cabrera JH, Smith AL, Chen XS, Ford HL, Zhao R. Structure- function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nat Struct Mol Biol. 2013 Apr;20(4):447-53. doi: 10.1038/nsmb.2505. Epub 2013 Feb 24. PMID: 23435380; PMCID: PMC3618615.

30: Krueger AB, Dehdashti SJ, Southall N, Marugan JJ, Ferrer M, Li X, Ford HL, Zheng W, Zhao R. Identification of a selective small-molecule inhibitor series targeting the eyes absent 2 (Eya2) phosphatase activity. J Biomol Screen. 2013 Jan;18(1):85-96. doi: 10.1177/1087057112453936. Epub 2012 Jul 20. PMID: 22820394; PMCID: PMC3893891.

31: Robin TP, Smith A, McKinsey E, Reaves L, Jedlicka P, Ford HL. EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance. Mol Cancer Res. 2012 Aug;10(8):1098-108. doi: 10.1158/1541-7786.MCR-12-0086. Epub 2012 Jun 20. PMID: 22723308; PMCID: PMC3432289.

32: Smith AL, Robin TP, Ford HL. Molecular pathways: targeting the TGF-β pathway for cancer therapy. Clin Cancer Res. 2012 Sep 1;18(17):4514-21. doi: 10.1158/1078-0432.CCR-11-3224. Epub 2012 Jun 18. PMID: 22711703.

33: Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A, Ford HL. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene. 2013 Mar 14;32(11):1341-50. doi: 10.1038/onc.2012.164. Epub 2012 May 14. PMID: 22580613; PMCID: PMC4502956.

34: Wang CA, Jedlicka P, Patrick AN, Micalizzi DS, Lemmer KC, Deitsch E, Casás- Selves M, Harrell JC, Ford HL. SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer. J Clin Invest. 2012 May;122(5):1895-906. doi: 10.1172/JCI59858. Epub 2012 Apr 2. PMID: 22466647; PMCID: PMC3336979.

35: Qamar L, Deitsch E, Patrick AN, Post MD, Spillman MA, Iwanaga R, Thorburn A, Ford HL, Behbakht K. Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer. Gynecol Oncol. 2012 May;125(2):451-7. doi: 10.1016/j.ygyno.2012.02.007. Epub 2012 Feb 12. PMID: 22333994; PMCID: PMC3607428.

36: Smith AL, Iwanaga R, Drasin DJ, Micalizzi DS, Vartuli RL, Tan AC, Ford HL. The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer. Oncogene. 2012 Dec 13;31(50):5162-71. doi: 10.1038/onc.2012.11. Epub 2012 Jan 30. PMID: 22286770; PMCID: PMC3342483.

37: Drasin DJ, Robin TP, Ford HL. Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res. 2011;13(6):226. doi: 10.1186/bcr3037. Epub 2011 Nov 1. PMID: 22078097; PMCID: PMC3326549.

38: Farabaugh SM, Micalizzi DS, Jedlicka P, Zhao R, Ford HL. Eya2 is required to mediate the pro-metastatic functions of Six1 via the induction of TGF-β signaling, epithelial-mesenchymal transition, and cancer stem cell properties. Oncogene. 2012 Feb 2;31(5):552-62. doi: 10.1038/onc.2011.259. Epub 2011 Jun 27. PMID: 21706047; PMCID: PMC3183358.

39: Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res. 2011 Mar 1;71(5):1883-92. doi: 10.1158/0008-5472.CAN-10-2252. PMID: 21363923; PMCID: PMC3250348.

40: Menke C, Goncharov T, Qamar L, Korch C, Ford HL, Behbakht K, Thorburn A. TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. PLoS One. 2011 Jan 14;6(1):e14527. doi: 10.1371/journal.pone.0014527. PMID: 21264287; PMCID: PMC3021504.

41: Micalizzi DS, Wang CA, Farabaugh SM, Schiemann WP, Ford HL. Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth. Cancer Res. 2010 Dec 15;70(24):10371-80. doi: 10.1158/0008-5472.CAN-10-1354. Epub 2010 Nov 5. PMID: 21056993; PMCID: PMC3072046.

42: Ford HL, Thompson EW. Mammary gland studies as important contributors to the cause of epithelial mesenchymal plasticity in malignancy. J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):113-5. doi: 10.1007/s10911-010-9182-0. PMID: 20544376.

43: Micalizzi DS, Farabaugh SM, Ford HL. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):117-34. doi: 10.1007/s10911-010-9178-9. Epub 2010 May 19. PMID: 20490631; PMCID: PMC2886089.

44: Coletta RD, McCoy EL, Burns V, Kawakami K, McManaman JL, Wysolmerski JJ, Ford HL. Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis. BMC Dev Biol. 2010 Jan 14;10:4. doi: 10.1186/1471-213X-10-4. PMID: 20074369; PMCID: PMC2823684.

45: Micalizzi DS, Ford HL. Epithelial-mesenchymal transition in development and cancer. Future Oncol. 2009 Oct;5(8):1129-43. doi: 10.2217/fon.09.94. PMID: 19852726.

46: Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Barón AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial- mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest. 2009 Sep;119(9):2678-90. doi: 10.1172/JCI37815. Epub 2009 Aug 24. PMID: 19726885; PMCID: PMC2735914.

47: McCoy EL, Iwanaga R, Jedlicka P, Abbey NS, Chodosh LA, Heichman KA, Welm AL, Ford HL. Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest. 2009 Sep;119(9):2663-77. doi: 10.1172/JCI37691. Epub 2009 Aug 24. PMID: 19726883; PMCID: PMC2735909.

48: Patrick AN, Schiemann BJ, Yang K, Zhao R, Ford HL. Biochemical and functional characterization of six SIX1 Branchio-oto-renal syndrome mutations. J Biol Chem. 2009 Jul 31;284(31):20781-90. doi: 10.1074/jbc.M109.016832. Epub 2009 Jun 4. PMID: 19497856; PMCID: PMC2742842.

49: McCoy EL, Kawakami K, Ford HL, Coletta RD. Expression of Six1 homeobox gene during development of the mouse submandibular salivary gland. Oral Dis. 2009 Sep;15(6):407-13. doi: 10.1111/j.1601-0825.2009.01560.x. Epub 2009 Apr 2. PMID: 19371398; PMCID: PMC2756531.

50: Christensen KL, Patrick AN, McCoy EL, Ford HL. The six family of homeobox genes in development and cancer. Adv Cancer Res. 2008;101:93-126. doi: 10.1016/S0065-230X(08)00405-3. PMID: 19055944.

51: Coletta RD, Christensen KL, Micalizzi DS, Jedlicka P, Varella-Garcia M, Ford HL. Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation. Cancer Res. 2008 Apr 1;68(7):2204-13. doi: 10.1158/0008-5472.CAN-07-3141. PMID: 18381426.

52: Behbakht K, Qamar L, Aldridge CS, Coletta RD, Davidson SA, Thorburn A, Ford HL. Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival. Cancer Res. 2007 Apr 1;67(7):3036-42. doi: 10.1158/0008-5472.CAN-06-3755. PMID: 17409410.

53: Christensen KL, Brennan JD, Aldridge CS, Ford HL. Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1). Oncogene. 2007 May 17;26(23):3406-14. doi: 10.1038/sj.onc.1210122. Epub 2006 Nov 20. PMID: 17130831.

54: Reichenberger KJ, Coletta RD, Schulte AP, Varella-Garcia M, Ford HL. Gene amplification is a mechanism of Six1 overexpression in breast cancer. Cancer Res. 2005 Apr 1;65(7):2668-75. doi: 10.1158/0008-5472.CAN-04-4286. PMID: 15805264.

55: Coletta RD, Christensen K, Reichenberger KJ, Lamb J, Micomonaco D, Huang L, Wolf DM, Müller-Tidow C, Golub TR, Kawakami K, Ford HL. The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6478-83. doi: 10.1073/pnas.0401139101. Epub 2004 Apr 26. PMID: 15123840; PMCID: PMC404070.

56: Coletta RD, Jedlicka P, Gutierrez-Hartmann A, Ford HL. Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia. 2004 Jan;9(1):39-53. doi: 10.1023/B:JOMG.0000023587.40966.f6. PMID: 15082917.
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